A previous entry detailed Dried Blood Spot Analysis: Preclinical Pros and Cons. Additional preclinical considerations include the ambiguity of acceptance by global regulatory agencies, none of which have issued definitive rulings on how they’ll handle New Drug...
Both advantages and challenges exist for use of dried blood spots during preclinical drug development. Advantages include small sample volumes coupled with easy shipment and storage. The amount of blood per spot varies (10 to 100 μL), but use of 15 to 20 μL seems...
Fundamentals Of Genetic Toxicology In The Pharmaceutical Industry Sept 2010 View more presentations from TigerTox. Historical Overview During the past 30 years, genetic toxicology testing has evolved technologically to play an important safety assessment role in the...
Preclinical models are developed to test lead compounds for toxicity and efficacy. This report 1) explores novel preclinical models (in vivo, in vitro, in silico, and systems biology) that show promise to expedite and improve the target validation, lead...
Seventh Wave Laboratories now offer a battery of gastrointestinal (GI) preclinical models (TIM) to help clients to assess the behavior of oral medications. The in vitro models are licensed from TNO, a Dutch contract research organization. The TIM system has proven...
Although drugs are usually targeted to be selective for a single protein, it is recognized that other proteins may also be affected, a phenomenon called polypharmacology. While off-target interactions can cause potentially harmful side-effects, in some cases, an...
