Dialogue
In the current study, using data from the DASH–Sodium trial, during screening when participants are consuming their normal dietary intake, we report a slope increment of an elevation in SBP of approximately 3 mmHg across the urinary Na + excretion range of 2–5 g/day in SS, but not SR participants. However, when assessed across the full range of observed urinary Na + excretion values we did not observe a positive correlation between SBP and urinary Na + excretion in either SS or SR participants. Significantly, despite urinary K + excretion of <1 g K + /day associating with higher SBP in SS and SR participants further increments in urinary K + excretion did not correlate with a reduction in SBP in either participant group. Furthermore, at baseline screening we did not observe a correlation between the urinary Na + :K + excretion ratio irrespective of the salt sensitivity of blood pressure. Following the DASH dietary intervention we observed no correlation between a urinary Na + :K + ratio and SBP in either SS or SR participants. As such our data, from the DASH–Sodium Trial, in US participants at both baseline screening and following a highly controlled dietary intervention does not support the hypothesis that a reduced urinary Na + :K + ratio will be beneficial in population level blood pressure reduction or support the proposal for a urinary Na + :K + molar ratio of <1 to lower blood pressure.
In a beneficial randomized regulated demonstration used in free-living non-fat loss managed professionals with a hateful SBP out of 132 mmHg and you may maybe not bringing blood pressure levels decreasing medication, K + intake is actually enhanced of the weight reduction consumption (thru fruit and you will vegetable intake) or lead K + pills
In contrast to the fresh Natural , INTERSALT , and you can INTERMAP training, you to definitely centered a population height positive connection between urinary Na + removal and you may blood pressure level, brand new Dashboard–Salt Demo permits the newest institution of your salt sensitiveness off bloodstream pressure in demonstration participants. On the other hand, during the SS players we noticed a slope increment out of an increase into the SBP of 1.step three mmHg for every step one g escalation in urinary Na + removal along the excretion directory of 3–5 g Na + /big date that’s contained in this normal mediocre list of day-after-day Na + consumption in america . Alternatively, when reviewed along side entire a number of observed urinary Na + removal, we seen zero association between urinary Na + removal and SBP either in SS otherwise SR players. الرهان على سباق الخيل I imagine this discrepancy anywhere between an optimistic relationships anywhere between SBP and you can urinary Na + excretion in expected directory of weight reduction Na + excretion of 3–5 grams/time no connection along side over list of opinions shows the perception of several players on the Dash–Salt study indicating higher quantities of urinary Na + excretion, greater than 5 g/go out, and you may relatively lower blood pressure level. Significantly, the benefits acquired in this data getting a rise in SBP in this step three–5 grams/big date Na + removal resembles you to definitely acquired on Absolute analysis which stated a positive slope increment regarding a-1. لعبة كازينو seven mmHg escalation in SBP each step one g rise in urinary Na + excretion across the exact same listing of Na + excretion viewpoints . The difference between the fresh observed increase in SBP responding in order to increased urinary Na + removal ranging from Dashboard-Salt and Natural ple dimensions and you may racial backgrounds of one’s members and you will (2) the possibility differences in solutions to determine pee posts out-of twenty-four-h pee collection compared to the an estimation from morning destination urine test throughout the Dashboard-Sodium in place of Absolute Data correspondingly. All of our study service guidelines so you’re able to restrict weight reduction Na + intake [5, 24] and you can advise that reduced slimming down salt consumption might only down SBP into the SS customers.
The influence of K + intake on blood pressure remains controversial, with conflicting data emerging from multiple clinical studies . In this study increased K + intake up to 40 mmol/day had no impact on blood pressure [22, 26]. A separate randomized placebo-controlled crossover trial was conducted in participants who have never received antihypertensive medication with mildly elevated blood pressure . Participants were maintained on their normal diet and received K + at 64 mmol/day for a 4-week period as either potassium chloride or bicarbonate-in this study there was no effect of K + supplementation on office blood pressure . In contrast in a randomized placebo-controlled, crossover study, in which untreated patients with a mean SBP of 145 mmHg blood pressure received 4 weeks of supplemental K + at 3 g/day and a diet relatively low in Na + reported a reduction in SBP of 3.9 mmHg. Beyond the highly controlled trials discussed above the PURE study reports that for each increment of 1 g/day of urinary K + excretion there is a reduction of 0.75 mmHg in SBP across the excretion range of <1.25 to 3 g K + /day . In the DASH–Sodium data, we observed an elevation in SBP in both SS and SR participants when urinary K + excretion was below 1 g/day. However, we did not observe any correlation between urinary K + excretion and SBP or an impact of urinary K + excretion on SBP over the range of <1 to >3 g K + excretion per day. We speculate that discrepancy between the PURE study data and our own analysis of the DASH-Sodium data may reflect the difference in SBP response to urinary K + excretion reported in PURE between Chinese and non-Chinese participants. Chinese participants exhibited a large reduction in SBP with increased urinary K + excretion versus a smaller SBP effect in participants from the rest of the world. As the DASH-Sodium trial did not contain https://datingranking.net/pl/silversingles-recenzja/ Chinese participants this may have influenced the outcome.